<SEC-DOCUMENT>0000919574-14-005519.txt : 20141006
<SEC-HEADER>0000919574-14-005519.hdr.sgml : 20141006
<ACCEPTANCE-DATETIME>20141006162927
ACCESSION NUMBER:		0000919574-14-005519
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20141006
DATE AS OF CHANGE:		20141006

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SYNTA PHARMACEUTICALS CORP
		CENTRAL INDEX KEY:			0001157601
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-82674
		FILM NUMBER:		141143151

	BUSINESS ADDRESS:	
		STREET 1:		45 HARTWELL AVE
		CITY:			LEXINGTON
		STATE:			MA
		ZIP:			02421
		BUSINESS PHONE:		781-274-8200

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CxSynta LLC
		CENTRAL INDEX KEY:			0001388171
		IRS NUMBER:				020604347
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		731 ALEXANDER ROAD
		STREET 2:		BUILDING 2
		CITY:			PRINCETON
		STATE:			NJ
		ZIP:			08540
		BUSINESS PHONE:		609-419-1800

	MAIL ADDRESS:	
		STREET 1:		731 ALEXANDER ROAD
		STREET 2:		BUILDING 2
		CITY:			PRINCETON
		STATE:			NJ
		ZIP:			08540
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>d6154609_13da.txt
<TEXT>


                        SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                      Under the Securities Exchange Act of 1934

                                (Amendment No. 12)

                            Synta Pharmaceuticals Corp.
                                 (Name of Issuer)

                                   Common Stock
                          (Title of Class of Securities)

                                    87162T206
                                  (CUSIP Number)

                             Mr. Heath N. Weisberg
                               Caxton Corporation
                           731 Alexander Road, Bldg. 2
                           Princeton, New Jersey 08540
                                 (609) 919-7608
          (Name, Address and Telephone Number of Person Authorized to
                       Receive Notices and Communications)

                                    09/30/2014
             (Date of Event which Requires Filing of this Statement)


If the filing person has previously filed a statement on Schedule 13G to
report the acquisition that is the subject of this Schedule 13D, and is
filing this schedule because of Section 240.13d-1(e), 240.13d-1(f) or
240.13d-1(g), check the following box. | |

Note:  Schedules filed in paper format shall include a signed original and
five copies of the schedule, including all exhibits.  See Section
240.13d-7 for other parties to whom copies are to be sent.

*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class
of securities, and for any subsequent amendment containing information
which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).


 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    CxSynta LLC
    02-0604347

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    WC

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    Delaware

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    7,761,716

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    7,761,716

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    7,761,716

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     7.4%

 (14) Type of Reporting Person (See Instructions).
     OO

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Caxton Corporation
    22-2437619

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    AF

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    Delaware

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    21,643,183

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    21,643,183

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    21,643,183

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     20.7%

 (14) Type of Reporting Person (See Instructions).
    CO

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2011 Family Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    125,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    125,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    125,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.1%

 (14) Type of Reporting Person (See Instructions).
    OO


 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2011-B Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    125,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    125,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    125,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.1%

 (14) Type of Reporting Person (See Instructions).
    OO

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2011-C Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    125,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    125,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    125,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.1%

 (14) Type of Reporting Person (See Instructions).
    OO

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2011-D Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    125,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    125,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    125,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.1%

 (14) Type of Reporting Person (See Instructions).
    OO

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2012-A Synta Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    475,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    475,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    475,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.5%

 (14) Type of Reporting Person (See Instructions).
    OO

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2012-B Synta Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    475,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    475,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    475,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.5%

 (14) Type of Reporting Person (See Instructions).
    OO

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2012-C Synta Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    475,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    475,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    475,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.5%

 (14) Type of Reporting Person (See Instructions).
    OO

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2012-D Synta Investment Trust

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    475,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    475,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    475,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.5%

 (14) Type of Reporting Person (See Instructions).
    OO

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner 2012 Family Trust B

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    OO

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    New York

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
      3,100,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
      3,100,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
      3,100,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     3.0%

 (14) Type of Reporting Person (See Instructions).
    OO

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    OB Select Opportunities, LLC
    22-3623004

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    WC

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    Delaware

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
      5,460,000

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
      5,460,000

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
      5,460,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     5.2%

 (14) Type of Reporting Person (See Instructions).
    OO

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Ben-Ur, David

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    PF

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    United States

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    6,200

 (8) Shared Voting Power:
    0

 (9) Sole Dispositive Power:
    6,200

 (10) Shared Dispositive Power:
    0

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    6,200

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.0%

 (14) Type of Reporting Person (See Instructions).
     IN

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Krishnamurthy, Arvind

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    PF

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    United States

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    5,000

 (8) Shared Voting Power:
    0

 (9) Sole Dispositive Power:
    5,000

 (10) Shared Dispositive Power:
    0

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    5,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.0%

 (14) Type of Reporting Person (See Instructions).
     IN

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Shteinbuk, Yuriy

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    PF

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    United States

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    3,000

 (8) Shared Voting Power:
    0

 (9) Sole Dispositive Power:
    3,000

 (10) Shared Dispositive Power:
    0

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    3,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.0%

 (14) Type of Reporting Person (See Instructions).
     IN

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Weisberg, Heath

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    PF

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    United States

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    3,000

 (8) Shared Voting Power:
    0

 (9) Sole Dispositive Power:
    3,000

 (10) Shared Dispositive Power:
    0

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    3,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.0%

 (14) Type of Reporting Person (See Instructions).
     IN

 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Wolfe, Jason

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    PF

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    United States

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    4,000

 (8) Shared Voting Power:
    0

 (9) Sole Dispositive Power:
    4,000

 (10) Shared Dispositive Power:
    0

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    4,000

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     0.0%

 (14) Type of Reporting Person (See Instructions).
     IN


 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    KFO HOLDINGS LLC
    46-4139835

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    WC

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    United States

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    0

 (8) Shared Voting Power:
    8,421,467

 (9) Sole Dispositive Power:
    0

 (10) Shared Dispositive Power:
    8,421,467

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    8,421,467

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     8.1%

 (14) Type of Reporting Person (See Instructions).
     OO


 (1) Names of Reporting Persons.
     I.R.S. Identification Nos. of above persons (entities only).

    Kovner, Bruce

 (2) Check the Appropriate Box if a Member of a Group (See Instructions)  (a)|_|
                                                                          (b)|x|

 (3) SEC Use Only.

 (4) Source of Funds (See Instructions).
    AF,PF

 (5) Check if Disclosure of Legal Proceedings is Required Pursuant to Items
     2(d) or 2(e)  |_|

 (6) Citizenship or Place of Organization
    United States

Number of Shares Beneficially Owned by Each Reporting Person With:

 (7) Sole Voting Power:
    3,096,215

 (8) Shared Voting Power:
    27,143,183

 (9) Sole Dispositive Power:
    3,096,215

 (10) Shared Dispositive Power:
    27,143,183

 (11) Aggregate Amount Beneficially Owned by Each Reporting Person.
    30,239,398

 (12) Check if the Aggregate Amount in Row (11) Excludes Certain Shares
      (see instructions).  |_|

 (13) Percent of Class Represented by Amount in Row (11).
     29.0%

 (14) Type of Reporting Person (See Instructions).
     IN


Item 3.  Source and Amount of Funds or Other Consideration

     Item 3 is hereby amended by adding the following thereto:

      Mr. Kovner has expended, in aggregate, approximately $51,764,698
      to acquire 9,442,206 shares of Synta Pharmaceuticals Corp.  The
      purchase price for the shares of Common Stock acquired by Mr.
      Kovner was paid out of Mr. Kovner's personal funds.  67,695 of
      the outstanding shares of Common Stock directly owned by Mr.
      Kovner were issued to Mr. Kovner as compensation for his service
      on the Company's Board of Directors or certain of its committees.
      Mr. Kovner also was granted 44,500 options on the Common Stock
      of the Company as compensation in connection with his service on
      the Company's Board of Directors.

      CxSynta has expended an aggregate of approximately $92,662,082
      to purchase the 7,761,716 shares of Common Stock directly owned
      by it.  The purchase price for such acquired shares was paid out
      of CxSynta working capital.

      Mr. David Ben-Ur has expended, in aggregate, approximately
      $37,076 (excluding commissions) to acquire 6,200 shares of the
      Company.

      Mr. Arvind Krishnamurthy has expended, in aggregate, approximately
      $28,730 (excluding commissions) to acquire 5,000 shares of the
      Company.

      Mr. Yuriy Shteinbuk has expended, in aggregate, approximately
      $17,175 (excluding commissions) to acquire 3,000 shares of the
      Company.

      Mr. Heath Weisberg has expended, in aggregate, approximately
      $12,820 (excluding commissions) to acquire 3,000 shares of the
      Company.

      Mr. Jason Wolfe has expended, in aggregate, approximately
      $16,813 (excluding commissions) to acquire 4,000 shares of the
      Company.

      KFO Holdings LLC has expended, in aggregate, approximately
      $43,910,147 to acquire 8,223,281 shares of the company.  KFO
      Holdings LLC also received 976,522 shares (approx. cost of
      $3,611,276) of Common Stock of the Company as a transfer from Mr.
      Kovner.  KFO Holdings LLC transferred 778,336 shares (approx. cost
      of $6,693,690) of Common Stock to OB Select Opportunities, LLC.

      Kovner 2012 Family Trust B has expended, in aggregate, approximately
      $14,154,359 to acquire 3,100,000 shares of the company.

      OB Select Opportunities has expended an aggregate of approximately
      $6,000,000 to purchase the 1,600,000 shares of Common Stock directly
      owned by it.  OB Select Opportunities LLC received 3,081,664 shares
      (approx. cost of $19,999,999) of Common Stock of the Company as a
      transfer from Mr. Kovner.  OB Select Opportunities LLC received
      778,336 shares (approx. cost of $6,693,690) of Common Stock of the
      Company as a transfer from KFO Holdings LLC.

      With the exception of the Kovner 2012 Family Trust B, each of the
      trusts listed herein have received their respective shares of
      Common Stock of the Company as gifts from Mr. Kovner which represents
      2,400,000 shares (approx. cost of $14,749,211) of Common Stock.  Mr.
      Kovner also transferred 976,522 shares of Common Stock to KFO
      Holdings LLC and 3,081,664 shares of common stock to OB Select
      Opportunities LLC as described above.


Item 4.  Purpose of Transaction.

      Each of the shares of Common Stock of the Company that are
      indicated herein were acquired for investment purposes.  Based on
      a review of the investment, each of the Reporting Persons may, in
      the open market or otherwise, acquire, cause to be acquired,
      dispose of, or cause to be disposed of, Common Stock or other
      securities of the Company, or derivatives or other instruments
      related to the securities of the Company.

      Mr. Kovner currently serves as a Director of the Company.  In that
      capacity, he participates in the ordinary course in Board of
      Directors' related activities and may participate in the management
      of the Company.

      Except as set forth in this Schedule 13D, none of the reporting
      persons has any plans or proposals that relate to any of the matters
      referred to in paragraphs (a) through (j) of the instructions to Item 4
      of Schedule 13D.

Item 5.  Interest in Securities of the Issuer

     Subparagraph (a), (b) and (c) of Item 5 of the Schedule 13D is
     hereby amended and replaced by the following:

(a)  (i) CxSynta LLC beneficially owns 7,761,716 shares of Common Stock,
     representing approximately 7.4% of the 104,369,471 shares of Common
     Stock reported to be outstanding in the 10-Q dated August 06, 2014.
     The percentages used herein and in the rest of this Amendment No. 12
     are calculated based upon such number of outstanding shares.

     (ii) Caxton Corporation is the Manager of CxSynta LLC, KFO Holdings
     LLC and OB Select Opportunities LLC and as such, has voting and
     dispositive power with respect to the 7,761,716 shares beneficially
     owned by CxSynta LLC, the 8,421,467 shares beneficially owned by
     KFO Holdings LLC and the 5,460,000 shares beneficially owned by OB
     Select Opportunities LLC.  As a result, Caxton Corporation may
     be deemed to beneficially own 21,643,183 shares of Common Stock,
     representing approximately 20.7% of the total shares of Common
     Stock issued and outstanding.

     (iii) Kovner 2011 Family Trust beneficially owns 125,000 shares
     of Common Stock, representing approximately 0.1% of the total shares of
     Common Stock issued and outstanding. Mr. Kovner may be deemed to
     indirectly have voting and dispositive power with respect to such
     125,000 shares. As a result, Mr. Kovner may be deemed to beneficially
     own 125,000 shares of Common Stock, representing approximately 0.1% of
     the total shares of Common Stock issued and outstanding.

     (iv)  Kovner 2011-B Investment Trust beneficially owns 125,000 shares
     of Common Stock, representing approximately 0.1% of the total shares of
     Common Stock issued and outstanding.  Mr. Kovner may be deemed to
     indirectly have voting and dispositive power with respect to such
     125,000 shares.  As a result, Mr. Kovner may be deemed to beneficially
     own 125,000 shares of Common Stock, representing approximately 0.1%
     of the total shares of Common Stock issued and outstanding.

     (v)   Kovner 2011-C Investment Trust beneficially owns 125,000 shares
     of Common Stock, representing approximately 0.1% of the total shares of
     Common Stock issued and outstanding.  Mr. Kovner may be deemed to
     indirectly have voting and dispositive power with respect to such
     125,000 shares.  As a result, Mr. Kovner may be deemed to beneficially
     own 125,000 shares of Common Stock, representing approximately 0.1%
     of the total shares of Common Stock issued and outstanding.

     (vi)  Kovner 2011-D Investment Trust beneficially owns 125,000 shares
     of Common Stock, representing approximately 0.1% of the total shares of
     Common Stock issued and outstanding.  Mr. Kovner may be deemed to
     indirectly have voting and dispositive power with respect to such
     125,000 shares.  As a result, Mr. Kovner may be deemed to beneficially
     own 125,000 shares of Common Stock, representing approximately 0.1%
     of the total shares of Common Stock issued and outstanding.

     (vii) Kovner 2012-A Synta Investment Trust beneficially owns 475,000
     shares of Common Stock, representing approximately 0.5% of the total
     shares of Common Stock issued and outstanding.  Mr. Kovner may be
     deemed to indirectly have voting and dispositive power with respect to
     such 475,000 shares.  As a result, Mr. Kovner may be deemed to
     beneficially own 475,000 shares of Common Stock, representing
     approximately 0.5% of the total shares of Common Stock issued and
     outstanding.

     (viii)Kovner 2012-B Synta Investment Trust beneficially owns 475,000
     shares of Common Stock, representing approximately 0.5% of the total
     shares of Common Stock issued and outstanding.  Mr. Kovner may be
     deemed to indirectly have voting and dispositive power with respect to
     such 475,000 shares.  As a result, Mr. Kovner may be deemed to
     beneficially own 475,000 shares of Common Stock, representing
     approximately 0.5% of the total shares of Common Stock issued and
     outstanding.

     (ix)  Kovner 2012-C Synta Investment Trust beneficially owns 475,000
     shares of Common Stock, representing approximately 0.5% of the total
     shares of Common Stock issued and outstanding.  Mr. Kovner may be
     deemed to indirectly have voting and dispositive power with respect to
     such 475,000 shares.  As a result, Mr. Kovner may be deemed to
     beneficially own 475,000 shares of Common Stock, representing
     approximately 0.5% of the total shares of Common Stock issued and
     outstanding.

     (x)   Kovner 2012-D Synta Investment Trust beneficially owns 475,000
     shares of Common Stock, representing approximately 0.5% of the total
     shares of Common Stock issued and outstanding.  Mr. Kovner may be
     deemed to indirectly have voting and dispositive power with respect to
     such 475,000 shares.  As a result, Mr. Kovner may be deemed to
     beneficially own 475,000 shares of Common Stock, representing
     approximately 0.5% of the total shares of Common Stock issued and
     outstanding.

     (xi)  Kovner 2012 Family Trust B beneficially owns 3,100,000 shares
     of Common Stock, representing approximately 3.0% of the total shares
     of Common Stock issued and outstanding.  Mr. Kovner may be deemed to
     indirectly have voting and dispositive power with respect to such
     3,100,000 shares.  As a result, Mr. Kovner may be deemed to
     beneficially own 3,100,000 shares of Common Stock, representing
     approximately 3.0% of the total shares of Common Stock issued and
     outstanding.

     (xii) OB Select Opportunities LLC directly owns of 5,460,000
     shares of Common Stock, representing approximately 5.2% of the total
     shares of Common Stock issued and outstanding.  Mr. Kovner may be
     deemed to indirectly have voting and dispositive power with respect to
     such 5,460,000 shares.  As a result, Mr. Kovner may be deemed to
     beneficially own 5,460,000 shares of Common Stock, representing
     approximately 5.2% of the total shares of Common Stock issued and
     outstanding.

     (xiii) Mr. Ben-Ur is the Chief Investment Officer of Caxton Alternative
     Management LP and has sole beneficial ownership of 6,200 shares of
     Common Stock, representing approximately 0.0% of the total shares of
     Common Stock issued and outstanding.

     (xiv) Mr. Arvind Krishnamurthy is principal of Caxton Alternative
     Management LP and has sole beneficial ownership of 5,000 shares of
     Common Stock, representing approximately 0.0% of the total shares of
     Common Stock issued and outstanding.

     (xv) Mr. Yuriy Shteinbuk is associate of Caxton Alternative
     Management LP and has sole beneficial ownership of 3,000 shares of
     Common Stock, representing approximately 0.0% of the total shares of
     Common Stock issued and outstanding.

     (xvi) Mr. Heath Weisberg is general counsel of Caxton Alternative
     Management LP and has sole beneficial ownership of 3,000 shares of
     Common Stock, representing approximately 0.0% of the total shares of
     Common Stock issued and outstanding.

     (xvii) Mr. Jason Wolfe is trader of Caxton Alternative
     Management LP and has sole beneficial ownership of 4,000 shares of
     Common Stock, representing approximately 0.0% of the total shares of
     Common Stock issued and outstanding.

     (xviii)KFO Holdings LLC beneficially owns of 8,421,467 shares of
     Common Stock, representing approximately 8.1% of the total
     shares of Common Stock issued and outstanding.  Mr. Kovner may be
     deemed to indirectly have voting and dispositive power with respect to
     such 8,421,467 shares.  As a result, Mr. Kovner may be deemed to
     beneficially own 8,421,467 shares of Common Stock, representing
     approximately 8.1% of the total shares of Common Stock issued and
     outstanding.

     (xix) Mr. Kovner has sole beneficial ownership of 3,096,215 shares of
     Common Stock, which includes options to purchase 44,500 shares of
     Common Stock upon the exercise of such options. In addition, Mr. Kovner
     is the Chairman and sole shareholder of Caxton Corporation, the Manager
     of CxSynta LLC, KFO Holdings LLC and OB Select Opportunities LLC and as
     a result may be deemed to beneficially own 21,643,183 securities of the
     Company owned by CxSynta LLC, KFO Holdings LLC and OB Select
     Opportunities Select LLC.  Mr. Kovner may be deemed to indirectly have
     voting and dispositive power with respect to each of the following
     trusts and, as a result, may be deemed to beneficially own the
     5,500,000 securities of the Company owned by such trusts, in aggregate:
     Kovner 2012-A Synta Investment Trust; Kovner 2012-B Synta Investment
     Trust; Kovner 2012-C Synta Investment Trust; Kovner 2012-D Synta
     Investment Trust; 2011-B Investment Trust; 2011-C Investment Trust;
     2011-D Investment Trust; Kovner 2012 Family Trust B and Kovner 2011
     Family Trust. As a result of the foregoing, Mr. Kovner may be deemed
     to beneficially own an aggregate of 30,239,398 shares of Common Stock,
     representing approximately 29.0% of the total shares of Common Stock
     issued and outstanding.

     Mr. Kovner disclaims beneficial ownership of the shares of Common Stock
     owned directly by CxSynta LLC, KFO Holdings LLC and OB Select
     Opportunities LLC, except to the extent of his pecuniary interest
     therein.  Mr. Kovner also disclaims beneficial ownership of the shares
     of Common Stock directly owned by each of the aforementioned trusts.


(b)  Caxton Corporation and Mr. Kovner, as Chairman and sole shareholder of
     Caxton Corporation, the Manager of CxSynta LLC, KFO Holdings LLC and OB
     Select Opportunities, LLC, may be deemed to share voting and dispositive
     power over 7,761,716 shares of Common Stock owned directly by CxSynta
     LLC, over 8,421,467 shares of Common Stock owned directly by KFO
     Holdings LLC and 5,460,000 shares of Common Stock owned directly by
     OB Select Opportunities LLC.  Mr. Kovner may be deemed to share voting
     and dispositive power with respect to the aggregate 5,500,000 shares
     of Common Stock held by the following trusts: Kovner 2011-B Investment
     Trust, Kovner 2011-C Investment Trust, Kovner 2011-D Investment Trust,
     Kovner 2012-A Synta Investment Trust, Kovner 2012-B Synta Investment
     Trust, Kovner 2012-C Synta Investment Trust, Kovner 2012-D Synta
     Investment Trust, Kovner 2012 Family Trust B and Kovner 2011 Family
     Trust. Mr. Ben-Ur has sole voting and dispositive power over the
     6,200 shares of Common Stock owned directly by him.  Mr. Krishnamurthy
     has sole voting and dispositive power over the 5,000 shares of Common
     Stock owned directly by him. Mr. Shteinbuk has sole voting and
     dispositive power over the 3,000 shares of Common Stock owned
     directly by him.  Mr. Weisberg has sole voting and dispositive
     power over the 3,000 shares of Common Stock owned directly by him. Mr.
     Wolfe has sole voting and dispositive power over the 4,000 shares of
     Common Stock owned directly by him. In addition, Mr. Kovner has sole
     voting and dispositive power with respect to the 3,096,215 shares of
     Common Stock (which includes the options thereon) that he directly
     beneficially owns.


(c)  On September 30, 2014, KFO Holdings, LLC purchased 300,000 shares of
     Common Stock for approximately $923,130. As of September 30, 2014
     67,595 of the outstanding shares of Common Stock directly owned by Mr.
     Kovner were issued to Mr. Kovner as compensation for his service on the
     Company's Board of Directors or certain of its committees. Mr. Kovner
     also was granted 44,500 options on the Common Stock of the Company as
     compensation in connection with his service on the Company's Board
     of Directors.

     Except as reported in this statement on Schedule 13D, the Reporting
     Persons are not believed to have engaged in any other transactions in
     the Company's securities since the most recent filing of Schedule 13D.


Item 6.  Contracts, Arrangements, Understandings or Relationships
         with Respect to Securities of the Issuer.

     Item 6 is hereby amended by adding the following thereto:

     The information contained in Item 5 of this Amendment No.12 is
     incorporated by reference.

     Mr. Ben-Ur serves as Chief Investment Officer, Mr. Krishnamurthy serves
     as principal, Mr. Shteinbuk serves as associate, Mr. Weisberg serves as
     General Counsel and Mr. Wolfe serves as Trader of Caxton Alternative
     Management LP, an entity indirectly controlled by Mr. Kovner.  As
     such they have agreed, during the course of their employment with Caxton
     Alternative Management LP, to abide by certain policies and
     procedures applicable to Mr. Kovner as a Director of the Company.
     By reason of this agreement, Mr. Kovner, Mr. Ben-Ur, Mr. Krishnamurthy,
     Mr. Shteinbuk, Mr. Weisberg and Mr. Wolfe may be deemed to be members
     of a group.  Mr. Kovner, Mr. Ben-Ur, Mr. Krishnamurthy, Mr. Shteinbuk,
     Mr. Weisberg and Mr. Wolfe and all other Reporting Persons named herein,
     expressly disclaim beneficial ownership of the Common Stock of the
     other Reporting Persons, except to the extent they may have an interest
     in such other Reporting Person.

     Except as set forth herein, there are no contracts, arrangements,
     understandings or relationships (legal or otherwise) among the persons
     filing this Report or the Reporting Persons or between such persons and
     any other person with respect to any securities of the Company,
     including, but not limited to transfer or voting of any of the
     securities, finder's fees, joint ventures, loan or option
     arrangements, puts or calls, guarantees of profits, division of profits
     or losses, or the giving or withholding of proxies.


Item 7.  Material to Be Filed as Exhibits


<PAGE>


Signature


After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

                                        CxSynta LLC

Date: 10/06/2014                        By Caxton Corporation, Managing Member
                                        of CxSynta LLC,
                                        /s/ Heath N. Weisberg, as General
                                        Counsel and Chief Compliance Officer of
                                        Caxton Corporation

                                        Caxton Corporation

Date: 10/06/2014                        /s/ Heath N. Weisberg, as General
                                        Counsel and Chief Compliance Officer
                                        of Caxton Corporation


Date: 10/06/2014                        Kovner 2011 Family Trust

                                        /s/ Karen Cross, Vice President
                                        and Treasurer of Cadence Trust Company

Date: 10/06/2014                        Kovner 2011-B Investment Trust

                                        /s/ Karen Cross, Vice President
                                        and Treasurer of Cadence Trust Company

Date: 10/06/2014                        Kovner 2011-C Investment Trust

                                        /s/ Karen Cross, Vice President
                                        and Treasurer of Cadence Trust Company

Date: 10/06/2014                        Kovner 2011-D Investment Trust

                                        /s/ Karen Cross, Vice President
                                        and Treasurer of Cadence Trust Company

Date: 10/06/2014                        Kovner 2012-A Synta Investment Trust

                                        /s/ Karen Cross, Vice President
                                        and Treasurer of Cadence Trust Company

Date: 10/06/2014                        Kovner 2012-B Synta Investment Trust

                                        /s/ Karen Cross, Vice President
                                        and Treasurer of Cadence Trust Company

Date: 10/06/2014                        Kovner 2012-C Synta Investment Trust

                                        /s/ Karen Cross, Vice President
                                        and Treasurer of Cadence Trust Company

Date: 10/06/2014                        Kovner 2012-D Synta Investment Trust
                                        /s/ Karen Cross, Vice President
                                        and Treasurer of Cadence Trust Company

Date: 10/06/2014                        Kovner 2012 Family Trust B
                                        /s/ Karen Cross, Vice President
                                        and Treasurer of Cadence Trust Company

Date: 10/06/2014                        OB Select Opportunities, LLC

                                        By Caxton Corporation, Manager
                                        of OB Select Opportunities LLC,
                                        /s/ Heath N. Weisberg, as General
                                        Counsel and Chief Compliance Officer of
                                        Caxton Corporation

Date: 10/06/2014                        David Ben-Ur
                                        /s/ David Ben-Ur

Date: 10/06/2014                        Arvind Krishnamurhty
                                        /s/ Arvid Krishnamurthy

Date: 10/06/2014                        Yuriy Shteinbuk
                                        /s/ Yuriy Shteinbuk

Date: 10/06/2014                        Heath N. Weisberg
                                        /s/ Heath N. Weisberg

Date: 10/06/2014                        Jason Wolfe
                                        /s/ Jason Wolfe

Date: 10/06/2014                        KFO Holdings LLC

                                        By Caxton Corporation, Manager
                                        of KFO Holdings LLC,
                                        /s/ Heath N. Weisberg, as General
                                        Counsel and Chief Compliance Officer of
                                        Caxton Corporation

                                        Bruce S. Kovner
Date: 10/06/2014                        /s/ Heath N. Weisberg, as attorney
                                        in fact for Bruce Kovner


The original statement shall be signed by each person on whose behalf the
statement is filed or his authorized representative. If the statement is
signed on behalf of a person by his authorized representative (other than
an executive officer or general partner of the filing person), evidence of
the representative's authority to sign on behalf of such person shall be
filed with the statement: provided, however, that a power of attorney for
this purpose which is already on file with the Commission may be incorporated
by reference.  The name and any title of each person who signs the statement
shall be typed or printed beneath his signature.

ATTENTION: Intentional misstatements or omissions of fact constitute Federal
criminal violations (See 18 U.S.C. 1001).


</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>